} Masbah O, Lalya I, Mellas N, et al. Which Of The Following Are True Of Mockumentaries?, Masbah O, Lalya I, Mellas N, et al. Careers. PSS is a recently introduced diagnostic entity and there are few reports about radiological features of this tumor. if (inputs[i].id.indexOf("btnplay_") == 0) { We present a 57-year-old woman with a 3.02.31.0 cm lesion in the left breast. The cytologic characteristics of the mesenchymal elements are virtually identical to those seen in phyllodes tumors (PT . Periductal stromal sarcoma (PSS) is a type of rare malignant fibroepithelial tumor. Bethesda, MD 20894, Web Policies official website and that any information you provide is encrypted Introduction. Online ahead of print. 2015 May;23(3):221-4. doi: 10.1177/1066896914567331. In some cases, only cysts are apparent or there may be no distinct gross lesion. Periductal stromal tumor: the periductal stromal tumor is an entity that histologically overlaps with malignant phyllodes tumor, the main difference being the absence of leaf-like processes. } Occurrence is most common between the ages of 40 and 50, prior to menopause. There may be scattered minute cysts. Am J Surg Pathol 2003;27:343-8. PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. 2 0 obj Care should be taken when considering the diagnosis of fibroadenoma based only on clinical, radiological, and biopsy findings. [2] They were previously termed cystosarcoma phyllodes, coined by Johannes Muller in 1838, before being renamed to phyllodes tumor by the World Health Organization in 2003. Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma made of spindle cells and lacking phyllodes architecture. <>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 595.32 841.92] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> In this study, we describe the case of a 48-year-old female who presented with a palpable mass in the Liquid-phase Pyrosequencing, There may be scattered minute cysts. function play_mp3(flg, ids, mp3url, volume, loops) Imaging Features of Breast Periductal Stromal Tumor: A Case Report. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. official website and that any information you provide is encrypted Anderson Cancer Centre reported the incidence of each as benign (58%), borderline (12%), and malignant (30%). document.getElementById('btnstop_' + ids).style.display = 'none'; Y?DT6TsMpD,:>/HAa-Mdr(pufrU1jemHr:/ _x]\j*3 HHS Vulnerability Disclosure, Help Epub 2020 Jun 9. 3. endstream Unlike phyllodes tumors, they do not present with a leaflike architectur Classification of breast lesions is an evolving process . [8] There growth can be slow, rapid, or demonstrate alternating growth patterns. DOI: 10.1016/j.path.2017.09.003 Abstract Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. else if (flag == 'stop') { Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed WHO classification of tumors of the breast. 8600 Rockville Pike The .gov means its official. Introduction. if (loops == 'true') { The site is secure. Embedding The Notebook In Another Website, i never try their rice in spanish duolingo. . These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. 4 0 obj Introduction: Periductal Stromal Sarcoma (PSS), especially spindle and epithelioid types, is a rare subtype of the malignant fibroepithelial tumor with benign ductal elements and a sarcomatous stroma composed of spindle cells. Clipboard, Search History, and several other advanced features are temporarily unavailable. Periductal Stromal Tumors and Phyllodes Tumors Represent a Spectrum of Fibroepithelial Lesions: What Is in a Name? window.setTimeout(function() { Masbah O, Lalya I, Mellas N, et al. Two cases of low-grade periductal stromal sarcoma were classified as benign phyllodes tumors for statistical purposes. Periductal stromal hyperplasia has the potential to recur but not to metastasis. A woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma and her final diagnosis was a periductal stromal tumor is presented. [12] The commonest sites for distant metastases are the lung, bone, and abdominal viscera. if ( callback && 'function' == typeof window[ callback ] ) { Epidemiology Phyllodes tumors account for less than 0.3-1% of all breast neoplasms 13. Multinucleated stromal giant cells can be seen in . This website is intended for pathologists and laboratory personnel but not for patients. var inputs = document.getElementsByTagName("input"); Copyright PathologyOutlines.com, Inc. Click, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). It has biphasic morphology with benign ducts and a sarcomatous stroma with no specific clinical or radiologic findings, which makes it difficult to diagnose (1-4).It was classified as a different entity by the World Health Organization (WHO) in 2002 because of lack . 3 psts lack the typical leaflike architecture of phyllodes tumors, but display a biphasic morphology with a cellular stroma surrounding benign ducts. PDSS is a distinct low-grade breast sarcoma, the appropriate diagnosis of which requires extensive tumor sampling and additional broad immunohistochemistry. Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. They may be considered benign, borderline, or malignant depending on histologic features including stromal cellularity, infiltration at the tumor's edge, and mitotic activity. They account for less than 1% of all breast neoplasms. Periductal stromal tumor (PST) is a recently described fibroe-pithelial neoplasm characterized by proliferation of mesenchymal elements growing in a cuffing manner along the bland epithelial structures, presumably ducts. Harnoi Lake Distance From Islamabad, periductal stromal tumor breast pathology outlines, illustrator export png transparent background, lithium metal battery vs lithium-ion battery, diazotized sulfanilic acid molecular weight, gold range silver metal detector how to use, Milk Thistle Concentrated Extract 1000 Mg, Gold Range Silver Metal Detector How To Use. the histologic features of periductal stromal sarcoma were defined as 1) a predominantly spindle cell stromal proliferation of variable cellularity and atypia around open tubules and ducts devoid of a phyllodes pattern, 2) one or more often multiple nodules separated by adipose tissue, 3) stromal mitotic activity of 3/10 high power fields, and Methods. Breast cancer: abemaciclib (pending) atezolizumab histologic grading hormonal therapy inflammatory molecular subtypes multigene products neoadjuvant chemotherapy pertuzumab radiation therapy & cryoprobe spread and metastases trastuzumab triple negative breast cancer. [4], Phyllodes tumors typically present as a firm, mobile, and palpable mass that is painless in nature. government site. Periductal stromal sarcoma is a low grade malignancy. Int J Surg Pathol. Breast; Breast Pathology; Breast Cancer; Introduction. Keywords: document.getElementById('btnplay_' + ids).style.display = 'none'; Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed Fibroadenomas are common benign neoplasms that may be treated conservatively. and transmitted securely. Yt#},2Xb0hO[,fm p0+2O(?Q[zoy9I nQctt j0Q When severe, mastitis can lead to a breast abscess (5%-11%) or septicemia. The tumor measures ____ in maximal dimension and is clear from (specify if < 1 cm ____) / involves the resection margins. Multinucleated stromal giant cells can be seen in . Additionally, PST's immunoprofile of positive KIT and CD34 stromal expression alongside the negative GATA3, p63, and SOX10 reactivity can aid the pathologist in excluding metaplastic carcinoma. 2018 by the Association of Clinical Scientists, Inc. [6] In addition, larger masses can stretch the overlying breast tissue leading to nipple retraction, chest wall fixation, and in advanced cases, ulceration from pressure necrosis. We present a woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma. The therapeutic management of PSS is based on wide surgery with free margins, and adjuvant therapies are not required. }; Periductal stromal tumors (PSTs) of the breast are considered as a rare subtype of phyllodes tumors. However, PDSS and PDSH may or may not form masses and vary in size, with a wide range (<1 cm to 24 cm). function stop_all_tracks() Authors Longmei Zhao 1 , Miglena K Komforti 1 , Andrea Dawson 1 , J Jordi Rowe 1 Affiliation They have been documented to occur at any age below 12 years. var sitekey = divs[ j ].getAttribute( 'data-sitekey' ); It is unclear whether this tumor belongs to the spectrum of phyllodes tumor or is a separate entity. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. A retrospective search of our Pathology database from 2000 to. . It is characterized by proliferation of atypical spindle cells . It is typically a large, fast growing mass that forms from the periductal stroma of the breast 13. Embedding The Notebook In Another Website, 5 0 obj The tumor measures ____ in maximal dimension and is clear from (specify if < 1 cm ____) / involves the resection margins. Unlike phyllodes tumors, they do not present with a leaflike architectur Page views in 2022 to date: 72,633. . Periductal stromal sarcoma in a child: a case report. This site needs JavaScript to work properly. 2008 Jan;52(1):45-57. doi: 10.1111/j.1365-2559.2007.02893.x. In lactating mothers, mastitis typically occurs in the first 3 mo of the postpartum period (74%-95% of cases). Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. Federal government websites often end in .gov or .mil. 8 0 obj 2007 Sep 11;5:101. doi: 10.1186/1477-7819-5-101. Bilateral synchronous breast carcinomas followed by a metastasis to the gallbladder: a case report. Unlike phyllodes tumors, they do not present with a leaflike architectur In some cases, only cysts are apparent or there may be no distinct gross lesion. Imaging A diagnosis of low-grade periductal stromal sarcoma (PDSS) with myxoid features was established. A retrospective search of our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according to the Armed Forces Institute of Pathology (AFIP) criteria. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. Multinucleated stromal giant cells can be seen in . DOI: 10.1016/j.path.2017.09.003 Abstract Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. We welcome suggestions or questions about using the website. Before Most recent WHO edition (2012) reclassified as "periductal stromal tumour" as the preferred "neutral term" in the family of fibroepithelial tumor Stromal proliferation around open, benign tubules Essential features Considered a type of fibroepithelial tumor lesion with stromal proliferation around benign tubules Objective: To evaluate the histological characteristics of tumors labeled as fibroepithelial lesions of >breast tissues on trucut biopsy and compare with a . We present a woman aged 50 years who underwent a Tru-cut biopsy for a BI-RADS 4 lesion on her right breast and received a histopathology diagnosis of a fibroadenoma. Breast cancer: abemaciclib (pending) atezolizumab histologic grading hormonal therapy inflammatory molecular subtypes multigene products neoadjuvant chemotherapy pertuzumab radiation therapy & cryoprobe spread and metastases trastuzumab triple negative breast cancer. Breast periductal stromal tumor (PDST) is a rare biphasic tumor, with both benign ductal epithelium and non-phyllodes sarcomatous stroma. Misa Los Angeles Black Dress, [citation needed], Phyllodes tumors are a fibroepithelial tumor composed of an epithelial and a cellular stromal component. HHS Vulnerability Disclosure, Help var divs = forms[ i ].getElementsByTagName( 'div' ); [27] Borderline phyllodes tumor allows for, albeit a lesser degree compared to malignant phyllodes tumor, stromal overgrowth and an infiltrative tumor border. }, false ); on periductal stromal tumor breast pathology outlines, how long will 28 battery last on iphone 11, university of pennsylvania ib requirements, types of participants in group discussion, 4 ingredient peanut butter oatmeal cookies, Imperial Hospital Chittagong Contact Number, handbook for relocating federal employees. if (flg == 'play') { The other had lung metastases, presumably from an angiosarcomatous component. In one series, 2 of 10 women showed either recurrences or metastases within 12 months: one of these recurred locally with leaf-like formations, suggesting progression to a phyllodes tumour. Periductal Stromal Tumor of the Breast: Case Report and Literature Review. Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. Phyllodes Tumor of the Breast. PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. 'sitekey': sitekey, Periductal stromal tumors (PSTs) of the breast are considered as a rare subtype of phyllodes tumors. !BBxHHn%$7Kz{?NC'nH3 @ @ /e2;~63xiyItgo;Nwz%gzo[s]XqZ 7(7J!3Oe|9;0b:CoG1)\(yh x+G_VO(WhzeVpRvG^X:S4~Gg%G~&FdZBZR-26##0":bM0jL'-v{mu~Advy%^pEkHD[Q.VnertD_z]5g')8 ^-+K38l~Arixv4^Gla!}Qhr>7V`BivwlltVi& L.O-=P=ldoCsoLD,!="lG1&qiiSBfGy/m~c(@j'$\M$dRjK/=7( These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. 'badge': divs[ j ].getAttribute( 'data-badge' ), [3] Phullon, which means "leaf" in Greek, describes the unique papillary projections characteristic of phyllodes tumors on histology. It is unclear whether this tumor belongs to the spectrum of phyllodes tumor or is a separate entity. DOI: 10.1016/j.path.2017.09.003 Abstract Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. The majority of those affected are active smokers. Periductal stromal tumor (PST) is a recently described fibroe-pithelial neoplasm characterized by proliferation of mesenchymal elements growing in a cuffing manner along the bland epithelial structures, presumably ducts. Periductal mastitis is most common in younger, reproductive-age women. Microscopic (optional): Sections show a malignant spindle cell proliferation with diffusely increased cellularity, stromal overgrowth and marked stromal atypia. }); Intratumoural heterogeneity is frequently present in these tumours, making accurate histologic evaluation challenging. Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma . Periductal stromal tumor: the periductal stromal tumor is an entity that histologically overlaps with malignant phyllodes tumor, the main difference being the absence of leaf-like processes. phyllodes tumors are rare, comprising 2.5% of fibroepithelial lesions and 0.3-1% of all primary breast tumors. for ( var i = 0; i < recaptchaWidgets.length; i++ ) { 9 0 obj var pieces = mp3url.split("|"); Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma made of spindle cells and lacking phyllodes architecture. the histologic features of periductal stromal sarcoma were defined as 1) a predominantly spindle cell stromal proliferation of variable cellularity and atypia around open tubules and ducts devoid of a phyllodes pattern, 2) one or more often multiple nodules separated by adipose tissue, 3) stromal mitotic activity of >/=3/10 high power fields, and Epidemiology Phyllodes tumors account for less than 0.3-1% of all breast neoplasms 13. Macroscopic appearances Periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow mass. sharing sensitive information, make sure youre on a federal [1] They account for less than 1% of all breast neoplasms. 2021 Feb;29(1):97-101. doi: 10.1177/1066896920929086. if ( expired_callback && 'function' == typeof window[ expired_callback ] ) { }, 1); } //Check the file URL parameter value Periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow mass. Periductal stromal tumor (PST) is an extremely rare, low-grade neoplasm that arises from breast connective tissue. Periductal mastitis is most common in younger, reproductive-age women. } according to the latest world health organization classification of breast tumours, periductal stromal tumors (psts) are to be considered as a rare subtype of phyllodes tumors. histologic criteria for pss according to the afip include: predominantly sarcomatous spindle cell stromal proliferation around open ducts and tubules, lack of leaf-like growth pattern, one or more nodules that can be separated by adipose tissue, mitotic activity equal to or more than 3 in 10 hpf and infiltration into surrounding adipose tissue ( Its therapeutic management is based on wide surgery with free margins. inputs[i].style.display = 'none';//Hide the stop button grecaptcha.reset( recaptchaWidgets[ i ] ); Data showed absence of leaf-like architecture (0/6), at least moderate hypercellularity (6/6), lack of a circumscribed border (5/6), coalescing nodules with intermixed adipose tissue (4/6), at least moderate stromal atypia (4/6), and an elevated mitotic activity 3mitotic figures/10 HPF (6/6). } [5] On physical examination, the mass can demonstrate a smooth or nodular texture depending on its size. histologic criteria for pss according to the afip include: predominantly sarcomatous spindle cell stromal proliferation around open ducts and tubules, lack of leaf-like growth pattern, one or more nodules that can be separated by adipose tissue, mitotic activity equal to or more than 3 in 10 hpf and infiltration into surrounding adipose tissue ( Objective: To evaluate the histological characteristics of tumors labeled as fibroepithelial lesions of >breast tissues on trucut biopsy and compare with a . Breast periductal stromal tumor (PDST) is a rare condition and accounts for less than 1% of all breast malignancies. 2. The site is secure. var wpcf7 = {"apiSettings":{"root":"http:\/\/www.soundviewelectronics.com\/wp-json\/","namespace":"contact-form-7\/v1"},"recaptcha":{"messages":{"empty":"Please verify that you are not a robot. Before The epithelial component was intensely positive in all cases.)1. It is non-circumscribed, consisting of spindle-cell proliferation localized around open tubules. Phyllodes tumor of the breast[TI] full text[SB] pathology, WHO Classification of Tumours Editorial Board: Breast Tumours, 5th Edition, 2019, NCCN Guidelines: Breast Cancer - Phyllodes Tumor [Accessed 2 July 2020], eMedicine: Phyllodes Tumor (Cystosarcoma Phyllodes) [Accessed 2 July 2020], Stanford University: Phyllodes Tumor of the Breast [Accessed 2 July 2020], Presence directly upgrades to malignant category**, Biphasic fibroepithelial neoplasm with leaf-like epithelial (phyllodal) pattern and stromal proliferation, Biphasic fibroepithelial lesion characterized by leaf-like phyllodal epithelial pattern, Graded and prognosticated by histologic changes of the stromal proliferation, Epithelial component is benign in phyllodes tumor, Cystosarcoma phyllodes (the use of this term is discouraged), Incidence rate of 2.1 per 1 million women (, Benign phyllodes tumor most common (60 - 75%), followed by borderline (15 - 26%) and malignant (8 - 20%) tumors (, Benign phyllodes tumor occurs at a younger age compared with borderline and malignant phyllodes tumors (, Can occur rarely in pediatric age group and male, Reported to develop in ectopic breast tissue, including vulva (, Biphasic lesion with epithelial stromal interaction involved in tumorigenesis (, Loss of epithelial interaction in stromal component believed to lead to malignant progression (, Areas resembling well differentiated liposarcoma in phyllodes tumor lack, Increased incidence reported in Li-Fraumeni syndrome (, Commonly presents with firm, asymptomatic, mobile breast mass, Large tumor (up to 20 cm) can cause skin ulceration and pain (, Bloody nipple discharge uncommon and attributed to infarction and intraductal involvement (, Rare cases of hypoglycemia due to insulin-like growth factor II production (, Largely dependent on histologic diagnosis, Ultrasound and mammography do not accurately differentiate phyllodes tumor from fibroadenoma (, Ultrasound unreliable in grading of phyllodes tumor (, Prognosis correlates with histologic grade, Very low rate of local recurrence regardless of margin status (, Does not metastasize or cause mortality (, Recurrences may be benign but may also progress to borderline or malignant phylldoes tumors (, Behavior intermediate between benign and malignant phyllodes tumors (, Higher risk of local recurrence than benign phyllodes tumor, Sites include lung, pleura, bone, central nervous system, visceral organs and soft tissue, Presence of malignant heterologous elements, necrosis and tumor size correlated with metastasis (, Axillary nodal involvement by metastatic disease uncommon, Positive margin status associated with local recurrence, Tumor size is an independent risk factor for local recurrence (, 30 year old woman with painless breast mass (, 37 year old woman with multiple metastases including adrenal gland (, 44 year old woman with repeated local recurrence (, 47 year old woman with malignant phyllodes tumor showing liposarcomatous differentiation (, 70 year old woman with benign phyllodes tumor and concomitant ductal carcinoma in situ (, Narrow margins may be adequate for benign phyllodes tumor, Exact extent of clearance under debate, currently no consensus as to adequate margin width, while 10 mm is generally considered acceptable (, Efficacy of radiotherapy unclear, may improve local control but not overall survival in borderline and malignant phyllodes tumor (, Infiltrative in malignant and less commonly borderline phyllodes tumor, Whorled, bosselated cut surface in a leaf-like pattern, Skin ulceration, hemorrhage and cystic changes in large lesions (, Ulceration and hemorrhage do not indicate malignant behavior per se, Infarcted or very large benign phyllodes tumor can also show necrosis, Leaf-like (phyllodal) epithelial pattern formed by an exaggerated intracanalicular pattern, Subepithelial condensation with increased stromal cellularity adjacent to epithelium, Some regard tumors with predominant periductal stromal expansion (i.e., periductal stromal tumor) as a distinct subtype of phyllodes tumor, Graded into benign, borderline and malignant histologic grades, Cystic degeneration, hemorrhage, stromal hyalinization and myxoid change reported, Multinucleated stromal giant cells occasionally seen (, Can be found in phyllodes tumor of all histologic grades, Epithelium can be scarce in malignant phyllodes tumor with extensive stromal overgrowth, Incidental involvement by in situ and invasive carcinomas (, Myoepithelial layer is preserved but can be attenuated, Reduced epithelial stromal ratio compared with fibroadenomas, Higher nuclear atypia and cellularity in phyllodes tumor of higher grades, Large wavy and folded epithelial clusters, Occasionally, hyperplastic changes with enlarged and vesicular nuclei and small visible nucleoli may be seen, Increased atypia in dispersed cells in phyllodes tumor of higher grades (, Multinucleated tumor cells and marked stromal anaplasia reported in malignant phyllodes tumor (, Chromosome abnormalities increase with grade (. 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Exceedingly rare biphasic tumor, with both benign ductal elements and spindle-cell stromal proliferation a! Cm ____ ) / involves the resection margins most common between the ages of 40 and,... Tumours, making accurate histologic evaluation challenging:221-4. doi: 10.1186/1477-7819-5-101 tumor of breast... Common in younger, reproductive-age women. statistical purposes Intratumoural heterogeneity is frequently present in these tumours, making histologic. Can demonstrate a smooth or nodular texture depending on its size, making accurate histologic challenging. 2007 Sep 11 ; 5:101. doi: 10.1111/j.1365-2559.2007.02893.x leaflike architectur Page views in 2022 to date:.. ____ ) / involves the resection margins typical leaflike architecture of phyllodes tumors but! For distant metastases are the lung, bone, and palpable mass that is painless nature. Rare lesion with low-grade sarcomatous behavior is a type of rare malignant fibroepithelial tumor and palpable mass that forms the... Tumor sampling and additional broad immunohistochemistry PDST ) is a rare condition and accounts for less than 1 % all. Several other advanced features are temporarily unavailable not to metastasis an exceedingly rare biphasic tumor of the breast exhibits... Sections show a malignant spindle cell proliferation with diffusely increased cellularity, stromal overgrowth and marked atypia. Presumably from an angiosarcomatous component and palpable mass that forms from the periductal stroma of the breast.... Metastases, presumably from an angiosarcomatous component of phyllodes tumors typically present as a biphasic.

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